The Best HIPAA-Compliant Video Call APIs for Telehealth Platforms

While there are many video call options available, if your platform serves US healthcare providers or patients, or handles protected health information (PHI) connected to US healthcare services, you need a video call API that’s HIPAA-compliant.

Here are the top HIPAA-compliant video call APIs for telehealth teams you should consider.

1. Whereby Embedded

Whereby Embedded is the standout choice for telehealth platform builders. The WebRTC video call software ensures that patients can join a session without any additional downloads.

The video call API is ISO 27001-certified, GDPR-compliant, and with frequent third-party HIPAA audits. Whereby also offers a standard Business Associate Agreement (BAA).

During integration, you need to configure meeting rooms to be HIPAA-compliant at the API level. For example, you should turn off third-party integration, disable certain features, lock meeting rooms by default, store recordings in your own S3 bucket, and so much more.

Whereby also offers HIPAA-compliant session transcriptions, cloud recordings, and live captions, making it ideal for teams who want a fully compliant stack.

Pricing:

• Compliance and BAA at no additional cost on Whereby Embedded Enterprise plans.

• $16.99/mo for the HIPAA add-on on the Whereby Embedded Build plan. Get in touch with

  our sales team

  to purchase this add-on.

Best for:

• Digital health companies' platforms that want to integrate video quickly and easily

• EHR vendors that want to include branded virtual calls in their stack

• Teams that want a compliance documentation their legal teams can quickly approve

• Platforms that want a solution that’s reliable and scalable, even in low-bandwidth scenarios

• Teams that want a video call API specifically built for telehealth

Not ideal for:

• Teams needing deep out-of-the-box Epic/Cerner EHR integration

• Hospital networks requiring on-premise or private-cloud data hosting

2. Daily.co

Daily is another choice for telehealth teams building AI into the clinical workflow. Built by engineers who wrote the WebRTC specification, it meets HIPAA and GDPR compliance requirements.

Its HIPAA architecture has no cookies or browser local storage, randomized room identifiers, and no access to in-call data. Daily also integrates HIPAA-compliant transcription, AI-generated clinical notes, and voice-powered patient intake directly into its developer APIs.

Pricing: $500/month for the healthcare add-on (HIPAA+BAA). See full pricing here

Best for:

• Telehealth teams that are focused on building AI-first solutions

• Strong engineering teams that want maximum infrastructure control

Not ideal for:

• Companies on a tight budget. $500/month is a fixed cost, excluding any participant minutes or usage-based pricing

• Developers or engineering teams who want low-configuration compliance

3. Vonage Video API

The Vonage Video API is an enterprise-grade option for healthcare teams that need video as part of a broader communication stack.

Vonage provides Video, Voice, and SMS APIs under a single BAA, with independent third-party HIPAA audits conducted on an ongoing basis. So if your telehealth product needs appointment reminders via SMS, incoming patient calls, in-app messaging, and video visits, Vonage covers all of it under one compliance umbrella.

Pricing: Contact sales.

Best for:

• Healthcare platforms needing voice, SMS, and video from a single provider

• Organizations that want AI-enabled programmable communications built into the stack

Not ideal for:

• Lean teams moving fast. Vonage's infrastructure depth is great for large organizations, but adds friction for teams who want to move quickly.

4. Zoom SDK

Zoom can be HIPAA compliant, but it is not compliant by default, and the path to compliance is more involved than most teams expect. A signed BAA is required, and it only applies to qualifying paid plans like the Zoom for healthcare stack.

Since Zoom is AI-first, certain AI Companion features may not be available for teams with BAAs in place. Beyond the BAA, teams must also correctly configure the platform, which might not be easy since the SDK integration has been said to be complex compared to web-first alternatives.

Compliance is the responsibility of the Security Officer and Privacy Officer, who must ensure Zoom is configured correctly and used compliantly across the workforce.

Pricing: Contact Sales

Best for:

• Organizations are already invested in the broader Zoom ecosystem

• Mid-to-large platforms where Epic or Cerner EHR interoperability is a priority

• Patient populations where familiarity with Zoom meaningfully reduces first-session drop-off

Not ideal for:

• Startups or lean engineering teams; integration is rated complex, and developer support is an extra high cost

• Teams that want a clean, self-contained compliance system. The three-layer shared-responsibility model (Zoom's obligations, your IT team's configuration, your workforce's behavior) requires active, ongoing management.

5. Pexip

Pexip is the enterprise choice for large health systems and hospital networks where data sovereignty, on-premise hosting options, and deep EHR integration (including Epic and Cerner/Oracle Health) are non-negotiable requirements.

Its architecture gives healthcare organizations complete control over where video data is stored and processed in self-hosted, private cloud, or controlled cloud environments.

The platform supports embedded video via APIs and SDKs with custom branding, policy-based access controls aligned to clinical and regulatory requirements, and a single operational dashboard for compliance monitoring across complex multi-site environments. ADA Title II accessibility compliance is also supported.

Pricing: Contact sales

Best for:

• Enterprise health systems and hospital networks with strict data governance

• Organizations with on-premise infrastructure mandates

• Complex multi-site deployments requiring centralized compliance monitoring

Not ideal for:

• Any company that isn’t operating at an enterprise scale. Pexip's implementation complexity, timeline, and cost structure make it overkill for startups and growth-stage companies.

• Without a dedicated IT and compliance team, the implementation process will slow you down considerably. It is not a self-serve option.

6. Twilio

Twilio offers HIPAA-eligible programmable video via a Business Associate Addendum (their BAA equivalent) for enterprise customers, covering video alongside HIPAA-eligible SMS and Voice.

Their group rooms support multi-party sessions including providers, patients, family members, and interpreters.

Twilio also previously announced the sunset of its video product before reversing course. So, teams building new healthcare infrastructure should factor in that product history when evaluating long-term infrastructure dependencies.

Pricing: Enterprise plan required for BAA access.

Best for

• Teams already deeply integrated into Twilio's broader communication stack

• Products needing combined HIPAA-eligible video, SMS, and voice under one vendor

Not ideal for:

• Teams starting fresh with no existing Twilio dependency.

• The shared-responsibility compliance model, the enterprise-only BAA requirement, and the product's uncertain history make it a difficult first choice for new builds.

7. CometChat

CometChat is a communication SDK covering video, voice, and in-app messaging and holds HIPAA, SOC 2, HITRUST, and PIPEDA certifications.

It signs BAAs and implements AES-256 and TLS 1.2 encryption, role-based permissions, MFA, and SSO. For telehealth apps where ongoing secure messaging between patients and providers is as central as the video call itself, CometChat delivers both under a single SDK and a unified compliance umbrella.

Pricing: Contact sales.

Best for:

• Care apps where continuous secure messaging is equally as important as video

• Development teams that want messaging and video under a single BAA

Not ideal for:

• Platforms where video quality and infrastructure reliability are the primary product concern. If video is the core clinical experience, opt for a software that specifically focuses on video calls for better performance.

What to evaluate when choosing a HIPAA-compliant video call API

Embedding a video API means your engineering team owns the integration. Even after choosing a vendor, HIPAA compliance is a shared responsibility. So, beyond signing a BAA, your platform should also implement and configure the technology correctly to securely handle protected health information (PHI).

So when comparing video call solutions, evaluate these 4 key things to ensure you can be fully HIPAA compliant:

• Compliance: Does the video call vendor have a BAA they’re willing to sign? And do they undergo regular independent third-party HIPAA audits?

• Cost and accessibility: Does the vendor only offer a BAA to customers on a large enterprise plan, or is it accessible to all paying users?

• Architecture: Who has access to in-call audio/video data, and under what circumstances? Can the room names be randomized to avoid accidental PHI leakage in identifiers?

• Developer experience: How quickly can your team integrate this solution in a HIPAA-compliant manner? Are integrations available for web, iOS, and Android? How clear and updated is their HIPAA documentation?

Wrapping Up

Your video call API decision is one of the few infrastructure choices that's genuinely hard to undo. It impacts your regulatory compliance, patient experience, and cost structure at scale.

If you want a compliant video infrastructure that's designed for telehealth, easy to integrate, and built to scale, Whereby Embedded is the best option to consider.

To find out more about the HIPAA-compliant configuration, BAA requirements, and implementation, speak directly with our team.